Anti-RPA70 antibody produced in rabbit
SIGMA/SAB5701703
Product Type: Chemical
antibody product type | primary antibodies |
biological source | rabbit |
clone | monoclonal |
concentration | 1.65 mg/mL |
form | liquid |
Quality Level | 100 ![]() |
shipped in | wet ice |
species reactivity | human, mouse |
storage temp. | −20°C |
technique(s) | immunohistochemistry: 1:50-1:200 |
western blot: 1:500-1:2000 | |
UniProt accession no. | Q16518 ![]() ![]() |
General description: | This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq, Jul 2008] |
Immunogen: | A synthesized peptide derived from human RPA70 |
Physical form: | Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |
Storage Temp. | −20°C |