Anti-Phospho-ULK1-S757 antibody produced in rabbit
SIGMA/SAB5701793
Product Type: Chemical
antibody product type | primary antibodies |
biological source | rabbit |
clone | polyclonal |
concentration | 0.77 mg/mL |
form | liquid |
Quality Level | 100 ![]() |
shipped in | wet ice |
species reactivity | human, mouse, rat |
storage temp. | −20°C |
technique(s) | immunohistochemistry: 1:50-1:200 |
western blot: 1:500-1:2000 | |
UniProt accession no. | O75385 ![]() ![]() |
General description: | Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165). |
Immunogen: | A synthetic phosphorylated peptide around S757 of human Phospho-ULK1-S757 (NP_003556.1). |
Physical form: | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Storage Temp. | −20°C |