Anti-Phospho-CRK/CRKII-Y221 antibody produced in rabbit
SIGMA/SAB5701913
Product Type: Chemical
antibody product type | primary antibodies |
biological source | rabbit |
clone | monoclonal |
concentration | 0.53 mg/mL |
form | liquid |
Quality Level | 100 ![]() |
shipped in | wet ice |
species reactivity | rat, human |
storage temp. | −20°C |
technique(s) | western blot: 1:500-1:2000 |
UniProt accession no. | P46108 ![]() ![]() |
General description: | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008] |
Immunogen: | A phospho specific peptide corresponding to residues surrounding Y221 of human CRK/CRKII |
Physical form: | Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |
Storage Temp. | −20°C |