4-Hydroxyphenylpyruvate Dioxygenase from Streptomyces avermitilis
SIGMA/SAE0003 - recombinant, expressed in E. coli
Product Type: Chemical
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| form | liquid |
| mol wt | ~41.8 kDa |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| specific activity | ≥5 U/mg |
| storage temp. | −70°C |
| General description: | 4-Hydroxyphenylpyruvate Dioxygenase (4-HPPD) is a key enzyme in the catabolism of tyrosine and phenylalanine. 4-HPPD catalyzes the synthesis of homogenistate (2,5-dihydroxyphenylaceta Rat 4-HPPD has a minimum of 80% homology with human 4-HPPD. Rat 4-HPPD is expressed abundantly in hepatocytes. It is also expressed in kidney, particularly in epithelial cells of the proximal tubules and the distant tubules. 4-HPPD has been identified as a potential biomarker of drug-induced liver injury in rat studies. |
| Other Notes: | One unit will oxidize 1 μmole of molecular oxygen per minute at pH 7.0, 25 °C, in the presence of 4-hydroxyphenylpyruvate. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ≥5 U/mg |
| Storage Temp. | −70°C |
| Enzyme Commission (EC) Number | 1.13.11.27 ( BRENDA  | IUBMB ) |
| UNSPSC | 12352204 |