S-(5′-Adenosyl)-L-homocysteine ready made solution

SIGMA/SAE0099 - ≥98% (HPLC), 1 mg/ml in 0.02 M HCl

Synonym: 5′-Deoxy-S-adenosyl-L-homocysteine; AdoHcy; S-(5′-Deoxyadenosine-5′)-L-homocysteine; SAH

Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SAE0099-1ML	1 mL	$268.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
concentration	1 mg/mL
shipped in	dry ice
storage temp.	−20°C

General description:

S-(5′-Adenosyl)-L-homocysteine (SAH) is a compound that occurs biologically as a by-product of reactions which S-adenosyl-L-methionine-dependent methyltransferases catalyze. These enzymes use S-adenosyl-L-methionine (SAM) as the parent material for cellular methyl transfer processes, such as DNA methylation. In its turn, SAH is cleaved by SAH hydrolase to produce homocysteine and adenosine. The homocysteine pathway and the plasma measurement of SAM and SAH3 have been studied in relation to topics such as cancer, nutritional deficiencies, and Alzheimer′s disease. SAH has been used to develop various methyltransferase activity assays, such as the following:
• Multiwell plate assay for protein methyltransferase SET7/9 activity
• Fluorescence polarization (FP) assay
• HPLC assay coupled to fluorometric detection

WGK Germany	WGK 1
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352202

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