Vancomycin hydrochloride
SIGMA/SBR00001 - Ready Made Solution, 100 mg/mL in DMSO
Synonym: Vancomycin HCL
CAS Number: 1404-93-9
Empirical Formula (Hill Notation): C66H75Cl2N9O24 · xHCl
Molecular Weight: 1449.25 (free base basis)
Linear Formula: C66H75Cl2N9O24 · xHCl
Product Type: Chemical
antibiotic activity spectrum | Gram-positive bacteria |
biological source | Streptomyces orientalis |
color | colorless to faint tan |
concentration | 100 mg/mL in DMSO |
form | liquid |
mode of action | cell wall synthesis | interferes |
Quality Level | 200 ![]() |
storage condition | (Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.) |
storage temp. | −20°C |
Application: | Vancomycin hydrochloride may be used- • for the assessment of the antimicrobial activity of vancomycin hydrochloride against Mycobacterium tuberculosis in nonreplicating persistence (NRP) using low-oxygen-recovery assay (LORA) and against a luciferase reporter strain of M. tuberculosis in a fermentor-grown culture adapted to low oxygen conditions • for the estimation of biomass in a culture of various strains of bacteria • as a positive control for E. coli and Staphylococcus aureus in antibacterial activity assay. |
Biochem/physiol Actions: | Vancomycin is bactericidal in nature, where it inhibits the synthesis of peptidoglycan. It forms hydrogen bond with the peptidoglycan precursor UDP-N-acetylmuramylpentapeptid |
General description: | Vancomycin is a glycopeptide antibiotic, which was initially isolated from Streptomyces orientalis. It is effective against multidrug-resistant MRSA strain (methicillin-resistant Staphylococcus aureus). However, it is nephrotoxic as it is mainly excreted by the kidneys. It has a core heptapeptide having aliphatic amino acids at positions 1 and 3. It is mainly effective against gram-positive bacteria. |
Other Notes: | Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids |
Packaging: | 10ML |
Symbol | ![]() |
Signal word | Danger |
Hazard statements | H317 - H334 |
Precautionary statements | P261 - P272 - P280 - P284 - P302 + P352 - P304 + P340 + P312 |
Hazard Codes | Xi |
Risk Statements | 43 |
Safety Statements | 36/37 |
WGK Germany | WGK 2 |
Flash Point(F) | 188.6 °F - closed cup |
Flash Point(C) | 87 °C - closed cup |
Storage Temp. | −20°C |
UNSPSC | 51101500 |