Vancomycin hydrochloride

SIGMA/SBR00001 - Ready Made Solution, 100 mg/mL in DMSO

Synonym: Vancomycin HCL

CAS Number: 1404-93-9
Empirical Formula (Hill Notation): C₆₆H₇₅Cl₂N₉O₂₄ · xHCl
Molecular Weight: 1449.25 (free base basis)
Linear Formula: C₆₆H₇₅Cl₂N₉O₂₄ · xHCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SBR00001-10ML	10 mL	$72.80 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-positive bacteria
biological source	Streptomyces orientalis
color	colorless to faint tan
concentration	100 mg/mL in DMSO
form	liquid
mode of action	cell wall synthesis \| interferes
Quality Level	200
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.)
storage temp.	−20°C

Application:	Vancomycin hydrochloride may be used- • for the assessment of the antimicrobial activity of vancomycin hydrochloride against Mycobacterium tuberculosis in nonreplicating persistence (NRP) using low-oxygen-recovery assay (LORA) and against a luciferase reporter strain of M. tuberculosis in a fermentor-grown culture adapted to low oxygen conditions • for the estimation of biomass in a culture of various strains of bacteria • as a positive control for E. coli and Staphylococcus aureus in antibacterial activity assay.
Biochem/physiol Actions:	Vancomycin is bactericidal in nature, where it inhibits the synthesis of peptidoglycan. It forms hydrogen bond with the peptidoglycan precursor UDP-N-acetylmuramylpentapeptide, and forms a stoichiometric 1:1 complex. Thus, it prevents the growth of the glycan polymer of peptidoglycan by transglycosylase enzyme. It is a frequently used antibiotic for the treatment of peritonitis caused by gram-positive bacteria in patients with continuous ambulatory peritoneal dialysis. In patients with cirrhosis, it is used to control portal systemic encephalopathy. Mice with Clostridium difficile infection (CDI) had better clinical outcome when treated with vancomycin as opposed to the outcome on treatment with metronidazole.
General description:	Vancomycin is a glycopeptide antibiotic, which was initially isolated from Streptomyces orientalis. It is effective against multidrug-resistant MRSA strain (methicillin-resistant Staphylococcus aureus). However, it is nephrotoxic as it is mainly excreted by the kidneys. It has a core heptapeptide having aliphatic amino acids at positions 1 and 3. It is mainly effective against gram-positive bacteria.
Other Notes:	Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids
Packaging:	10ML

Symbol	GHS08
Signal word	Danger
Hazard statements	H317 - H334
Precautionary statements	P261 - P272 - P280 - P284 - P302 + P352 - P304 + P340 + P312
Hazard Codes	Xi
Risk Statements	43
Safety Statements	36/37
WGK Germany	WGK 2
Flash Point(F)	188.6 °F - closed cup
Flash Point(C)	87 °C - closed cup

Storage Temp.	−20°C
UNSPSC	51101500

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