Clarithromycin
SIGMA/SBR00011 - Ready Made Solution, 50 mg/mL in DMSO
Synonym: 6-O-methyl erythromycin
CAS Number: 81103-11-9
Empirical Formula (Hill Notation): C38H69NO13
Molecular Weight: 747.95
MDL Number: MFCD00865140
Linear Formula: C38H69NO13
Product Type: Chemical
| antibiotic activity spectrum | Gram-positive bacteria |
| color | colorless to faint yellow |
| concentration | 50 mg/mL in DMSO |
| form | liquid |
| ready-to-use solution | |
| InChI | 1S/C38H69NO13/c1-15-26-38 |
| InChI key | AGOYDEPGAOXOCK-KCBOHYOISA |
| mode of action | protein synthesis | interferes |
| Quality Level | 200  |
| SMILES string | N([C@@H]1[C@H]([C@@H](O[C |
| storage condition | dry media (Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.) |
| storage temp. | −20°C |
| Application: | Clarithromycin may be used for- • the study of the effects of clarithromycin on rate-dependent changes in QT, Tp-e and proarrhythmic events performed on arterially perfused rabbit left ventricular wedge preparations • the culture of parasites expressing GFP (green fluorescence protein) targeted to the apicoplast, to be further used for microscopy-based assays • the study of the synergism of NAB741 with clarithromycin in microtiter plates. |
| Biochem/physiol Actions: | Macrolides, such as clarithromycin, prevent protein synthesis in bacteria, by binding to 50S ribosomal subunit. It also binds to other ribosomal proteins, and prevents the translocation of pepti-dyl-tRNA. In patients with refractory asthma, it is capable of regulating the levels of interleukin-8 (IL-8), and neutrophil accumulation and activation in lungs. Thus, it might be used as an additional therapy in asthma to reduce noneosinophilic airway inflammation. |
| General description: | Clarithromycin is a macrolide antibiotic, which has both antibacterial and anti-inflammatory actions. It is a semi-synthetic 14-membered derivative of erythromycin A, which is resistant to degradation under acidic conditions. |
| Other Notes: | Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids |
| Packaging: | 2ML |
| Preparation Note: | Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids. |
| WGK Germany | WGK 1 |
| Flash Point(F) | 188.6 °F |
| Flash Point(C) | 87 °C |
| Storage Temp. | −20°C |
| UNSPSC | 51102829 |