Actinomycin D, Ready Made Solution

SIGMA/SBR00013 - from Streptomyces sp., 2 mg/mL in DMSO

Synonym: Actinomycin D solution from Streptomyces sp.; Actinomycin IV; Dactinomycin

CAS Number: 50-76-0
Empirical Formula (Hill Notation): C₆₂H₈₆N₁₂O₁₆
Molecular Weight: 1255.42
Linear Formula: C₆₂H₈₆N₁₂O₁₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SBR00013-1ML	1 mL	$165.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	neoplastics
biological source	Streptomyces sp.
color	dark orange
concentration	2 mg/mL in DMSO
description	Ready Made Solution
form	liquid
InChI	1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)
InChI key	RJURFGZVJUQBHK-UHFFFAOYSA-N
mode of action	DNA synthesis \| interferes
Quality Level	200
storage condition	protect from light
storage temp.	−20°C

Biochem/physiol Actions:	Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation. It is a cytotoxic inducer of apoptosis against tumor cells. The compound inhibits the proliferation of cells in a nonspecific way by forming a stable complex with double-stranded DNA (via deoxyguanosine residues), thus inhibiting DNA-primed RNA synthesis. It also causes single strand breaks in DNA. Actinomycin D has been shown to be an inhibitor of the minus-strand transfer step in reverse transcription, and is therefore used in studies and suppression of HIV-replication. It has also been shown to suppress programmed cell death of PC12 cells induced by etoposide, an inhibitor of topoisomerase II. In cell culture, actinomycin D is used as a selection agent. Actinomycin D binding to yeast in ribosomal RNA has been studied. The sensitivity of various strains of E. coli to actinomycin D and the mechanism of binding has been studied. Actinomycin D is also used in molecular biology as a DNA intercalator which blocks the progression of RNA polymerases.
Caution:	Actinomycin D solutions are very sensitive to light.
Packaging:	1ML
Preparation Note:	The 2 mg/mL solution may be further diluted in an appropriate buffer prior to use.

Symbol	GHS08
Signal word	Danger
Hazard statements	H350
Precautionary statements	P201 - P202 - P280 - P308 + P313 - P405 - P501
WGK Germany	WGK 3
Flash Point(F)	188.6 °F - closed cup
Flash Point(C)	87 °C - closed cup

Storage Temp.	−20°C
UNSPSC	12352200

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