Puromycin aminonucleoside Ready Made Solution
SIGMA/SBR00017 - 10 mg/mL in water
Synonym: 3′-Amino-3′-deoxy-N6,N6-dimethyladenosine
CAS Number: 58-60-6
Empirical Formula (Hill Notation): C12H18N6O3
Molecular Weight: 294.31
Linear Formula: C12H18N6O3
Product Type: Chemical
| antibiotic activity spectrum | Gram-positive bacteria |
| neoplastics | |
| parasites | |
| assay | ≥98% |
| concentration | 10 mg/mL in water |
| form | liquid |
| InChI | 1S/C12H18N6O3/c1-17(2)10- |
| InChI key | RYSMHWILUNYBFW-UHFFFAOYSA |
| mode of action | protein synthesis | interferes |
| Quality Level | 200  |
| SMILES string | N[C@H]1[C@@H](O)[C@H](N(C |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | Puromycin aminonucleoside is an aminonucleoside derivative of the known antibiotic puromycin. Puromycin aminonucleoside has been used in nephrology research, studying focal and segmental glomerulosclerosis, and in the induction of nephrosis in rats. Rats with puromycin aminonucleoside-induced nephrotic syndrome were used to study the excretion of sodium and NOx metabolites. Puromycin aminonucleoside has also been used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability. A puromycin aminonucleoside nephrosis model of rat glomerular disease was also used to study the role of the neuron-specific ubiquitin C-terminal hydrolase protein gene product 9.5 (PGP 9.5). |
| Preparation Note: | Puromycin aminonucleoside solution is provided at 10 mg/mL in water and could be further diluted in aqueous buffers to a working concentration of 10 μg/mL (1:1000). |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |