Nisin Ready Made Solution
SIGMA/SBR00021 - (20,000-40,000 IU/mL in 0.02N HCl)
Synonym: Nisaplin
CAS Number: 1414-45-5
Empirical Formula (Hill Notation): C143H230N42O37S7
Molecular Weight: 3354.07
Linear Formula: C143H230N42O37S7
Product Type: Chemical
antibiotic activity spectrum | Gram-positive bacteria |
biological source | Lactococcus lactis |
concentration | (20,000-40,000 IU/mL in 0.02N HCl) |
density | 1.02 g/mL |
form | solution |
InChI | 1S/C143H230N42O37S7/c1-24 |
InChI key | NVNLLIYOARQCIX-GSJOZIGCSA |
mode of action | cell membrane | interferes |
shipped in | dry ice |
SMILES string | O=C(N[C@H](C(NC(C(N[C@@H] |
storage temp. | −20°C |
Application: | Due to its wide range of antimicrobial activity, nisin is used as a shelf-life extender in a broad range of dairy and non-dairy products. |
Biochem/physiol Actions: | Nisin (Nisaplin) is produced by Lactococcus lactis. It is an effective lantibiotic peptide bactericidal agent. Nisin is a broad spectrum antimicrobial bacteriocin which affects Gram-positive bacteria, however, it has little or no effect on Gram-negative bacteria, yeasts or fungi. It was demonstrated that nisin has capability to inhibit the growth of almost all tested Gram-positive beer-spoilage bacteria. Of 122 Gram-positive bacteria strains (predominantly Lactobacilli and Pediococci), 93% were sensitive to 100 units of nisin. In contrast, out of the 32 Gram-negative strains tested, only the genus Flavobacter proved to be affected by nisin. Nisin exerts its antimicrobial activity by binding to lipid II which is a membrane-bound advanced intermediate involved in the biosynthesis of bacterial cell wall. By doing so, nisin sequesters lipid II from its functional location. In addition, the nisin-lipid II complex leads to formation of pores in the membrane causing cell death. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 1 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Density | 1.02 g/mL |
Storage Temp. | −20°C |
UNSPSC | 12352200 |