Solithromycin

SIGMA/SBR00037 - ≥98% (HPLC)

Synonym: 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone; CEM-101; OP-1068

Empirical Formula (Hill Notation): C₄₃H₆₅FN₆O₁₀
Molecular Weight: 845.01
MDL Number: MFCD30207880
Linear Formula: C₄₃H₆₅FN₆O₁₀
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SBR00037-10MG		No Price

Properties
Descriptions
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
assay	≥98% (HPLC)
form	powder
mode of action	protein synthesis \| interferes
Quality Level	200
storage temp.	−20°C

Application:	Solithromycin is a highly potent next-generation macrolide, the first fluoroketolide, which has potent activity against most macrolide-resistant strains. In vitro and in vivo studies have shown potent activity against S. pneumoniae as well as an extended spectrum of activity against CA-MRSA, enterococci, Mycobacterium avium and in animal models of malaria. It is also active against atypical bacteria, such as Legionella, Chlamydophila, Chlamydia, Mycoplasmaand Ureaplasma and against gonococci and other organisms that cause genitourinary tract infections.
Biochem/physiol Actions:	Solithromycin (CEM-101) is a novel fluoroketolide with improved antimicrobial effectiveness. This compound binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis. Like other ketolides, it should impair bacterial ribosomal subunit formation.
Other Notes:	Inxight:Drugs

Purity	≥98% (HPLC)
Storage Temp.	−20°C

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