Solithromycin
SIGMA/SBR00037 - ≥98% (HPLC)
Synonym: 2H-
Empirical Formula (Hill Notation): C43H65FN6O10
Molecular Weight: 845.01
MDL Number: MFCD30207880
Linear Formula: C43H65FN6O10
Product Type: Chemical
antibiotic activity spectrum | Gram-negative bacteria |
Gram-positive bacteria | |
assay | ≥98% (HPLC) |
form | powder |
mode of action | protein synthesis | interferes |
Quality Level | 200 ![]() |
storage temp. | −20°C |
Application: | Solithromycin is a highly potent next-generation macrolide, the first fluoroketolide, which has potent activity against most macrolide-resistant strains. In vitro and in vivo studies have shown potent activity against S. pneumoniae as well as an extended spectrum of activity against CA-MRSA, enterococci, Mycobacterium avium and in animal models of malaria. It is also active against atypical bacteria, such as Legionella, Chlamydophila, Chlamydia, Mycoplasmaand Ureaplasma and against gonococci and other organisms that cause genitourinary tract infections. |
Biochem/physiol Actions: | Solithromycin (CEM-101) is a novel fluoroketolide with improved antimicrobial effectiveness. This compound binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis. Like other ketolides, it should impair bacterial ribosomal subunit formation. |
Other Notes: | Inxight:Drugs ![]() ![]() |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |