Omadacycline
SIGMA/SBR00042 - ≥98% (HPLC)
CAS Number: 389139-89-3
Empirical Formula (Hill Notation): C29H40N4O7
Molecular Weight: 556.65
MDL Number: MFCD19443723
Linear Formula: C29H40N4O7
Product Type: Chemical
| antibiotic activity spectrum | Gram-negative bacteria |
| Gram-positive bacteria | |
| assay | ≥98% (HPLC) |
| form | powder |
| mode of action | protein synthesis | interferes |
| Quality Level | 100  |
| storage temp. | −20°C |
| Application: | Mode of Action: Interferes with protein synthesis Antibiotic Activity Spectrum: Gram-negative bacteria and Gram-positive bacteria. |
| Biochem/physiol Actions: | Omadacycline displays antimicrobial activities against a broad spectrum of organisms including Gram-positive, Gram-negative, anaerobic, and atypical bacteria.(3)(4) It inhibits bacterial protein synthesis by binding on the 30S subunit of the bacterial ribosome.(1)(2) Omadacycline is also effective against tetracycline efflux proteins in in vitro studies and protects against bacterial tetracycline resistance.(4) It has improved efficacy than other tetracycline drugs against acute bacterial skin and skin structure infections (ABSSSIs) and community-acquired bacterial pneumonia (CABP).(1)(2)(5) In nonclinical and ex vivo studies, omadacycline displays a low potential for cardiovascular toxicity.(6) |
| General description: | Omadacycline is an aminomethylcycline, a novel semisynthetic tetracycline-class antibiotic drug.(1)(2) It is distinguished from other tetracycline-class drugs like tigecycline and eravacycline at the C9 position with an aminomethyl substitution.(2) |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |