Acetyl-Amyloid β 25-35
SIGMA/SCP0002
Empirical Formula (Hill Notation): C47H83N13O15S1
Molecular Weight: 1102.31
Linear Formula: C47H83N13O15S1
Product Type: Chemical
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| assay | ≥95% (HPLC) |
| composition | Peptide Content, ≥70% |
| form | lyophilized |
| storage condition | protect from light |
| storage temp. | −20°C |
| UniProt accession no. | P05067   |
| Amino Acid Sequence: | Ac-Gly-Ser-Asn-Lys-Gly-Al |
| Application: | Acetyl-Amyloid β 25-35 has been used to prepare rat models with Alzheimer’s disease. |
| General description: | Amyloid-β (Aβ) peptides are a major component of the senile plaques characteristic of the Alzheimer brain. It is a type- I transmembrane protein. The amyloid β precursor protein is cleaved to amyloid peptides 36-43 amino acids in length. Aβ (25-35) represents the region that aggregates during plaque formation and is a functional domain implicated in both neurotrophic and neurotoxic effects. The gene encoding amyloid-β is localized on human chromosome 21. Acetylation may improve stability in in vitro and in vivo assays. |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |