Calpastatin Peptide Ac 184-210
SIGMA/SCP0063 - ≥95% (HPLC)
Empirical Formula (Hill Notation): C142H230N36O44S1
Molecular Weight: 3177.63
Linear Formula: C142H230N36O44S1
Product Type: Chemical
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| assay | ≥95% (HPLC) |
| composition | Peptide Content, ≥75% |
| form | lyophilized |
| storage condition | protect from light |
| storage temp. | −20°C |
| Amino Acid Sequence: | Ac-Asp-Pro-Met-Ser-Ser-Th |
| Application: | Calpastatin Peptide Ac 184-210 has been used as the endogenous calpain inhibitor to study its effects on myristoylated alanine-rich C kinase substrate (MARCKS) cleavage in mouse kidney cells. It has also been used as a calpain inhibitor to examine its effects on the formation of DNA-platinum adducts by cisplatin (CDDP) in neuronal cells. |
| Biochem/physiol Actions: | Calpastatin, a component of the calpain/calpastatin system, is a calpain (calcium-dependent cysteine protease) inhibitor. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. |
| Biochem/physiol Actions: | Calpastatin, located in the cytosol, is involved in selective protein cleavage in response to calcium signaling. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |