Caspase 3 Substrate
SIGMA/SCP0084
Empirical Formula (Hill Notation): C31H39N5O12
Molecular Weight: 673.67
Linear Formula: C31H39N5O12
Product Type: Chemical
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| assay | ≥95% (HPLC) |
| composition | Peptide Content, ≥80% |
| form | lyophilized |
| storage condition | protect from light |
| storage temp. | −20°C |
| Amino Acid Sequence: | Ac-Asp-Glu-Val-Asp-4M2NA |
| Application: | Caspase 3 Substrate has been used to determine caspase activity in esophageal squamous cell carcinoma EC109 cell line. |
| Application: | Caspase 3, a cysteine protease activator of caspase 6 and caspase 7, metabolizes amyloid-β 4A precursor protein. Caspase 3 may be detected using a variety of chromogenic and fluorogenic peptide substrates built around the DxxD (asp-x-x-asp) sequences DMQD and DEVD such as Ac-DMQD-pNa (Acetyl-Asp-Met-Gln-Asp-p |
| General description: | Caspase 3 belongs to the family of cysteinyl proteases, which regulate apoptosis. It is encoded by CASP-3 gene. Caspase 3 is important for normal brain development. Caspase 3 is involved in growth stimulation of surviving tumor cells. It is associated with neuronal apoptosis in Alzheimer′s disease. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |