Furin Inhibitor II
SIGMA/SCP0148
Synonym: Hexa-D-arginine amide
Empirical Formula (Hill Notation): C36H75N25O6
Molecular Weight: 954.14
Linear Formula: C36H75N25O6
Product Type: Chemical
| assay | ≥95% (HPLC) |
| composition | Peptide Content, ≥48% |
| form | lyophilized |
| storage condition | protect from light |
| storage temp. | −20°C |
| Amino Acid Sequence: | Mpa-Mpa-Mpa-Mpa-Mpa-Mpa |
| Application: | Furin Inhibitor II has been used as a furin inhibitor: • to study its effects on transforming growth factor β1 (TGF-β1) induced glial cell line-derived neurotrophic factor (GDNF) production in non-tumorigenic immortalized human granulosa cell line (SVOG). • to study its effect on cleavage of (Pro) renin receptor (PRR) induced by bovine serum albumin (BSA) in human kidney 2 (HK-2) cells. • in furin cleavage assay. |
| Biochem/physiol Actions: | Furin plays a role in processing several pro-proteins such as, bone morphogenetic protein 4 (BMP-4), insulin receptor and Notch1 receptor. It also processes human immune deficiency virus 1 (HIV-1) glycoprotein gp160, several metalloproteases and pro-β-nerve growth (pro-β-NGF) factor. Furin is also involved in cleaving transforming growth factor β1 (TGF-β1). |
| General description: | Furin is a calcium-dependent serine endoproteinase and belongs to the subtilisin-like proprotein/prohormone convertase (PC) family. It is distributed ubiquitously and has a rhythmic movement between the trans-Golgi network, cell surface and the endosomes. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |