Gastrin I (1-14)
SIGMA/SCP0152 - ≥92% (HPLC)
Empirical Formula (Hill Notation): C79H100N16O27
Molecular Weight: 1705.73
Linear Formula: C79H100N16O27
Product Type: Chemical
| assay | ≥92% (HPLC) |
| composition | Peptide Content, ≥75% |
| form | lyophilized |
| storage condition | protect from light |
| storage temp. | −20°C |
| Amino Acid Sequence: | Glp-Gly-Pro-Trp-Leu-Glu-G |
| Application: | Gastrin I (1-14) has been used: • as a component of gastric cancer stem/progenitor cell (GCSPC) medium for tumorsphere culture • as a supplement in organoid growth medium (OGM) for patient-derived organoid (PDO) • in viable lymphocytes culture for re-stimulation assay |
| Biochem/physiol Actions: | Gastrin is a linear polypeptide that induces the secretion of gastric acid (HCl) by parietal cells. |
| Biochem/physiol Actions: | The peptide gastrin I (1-14), which lacks a basic site, forms positive ions. Gastrin promotes the production and liberation of histamine in enterochromaffin-like cells through cholecystokinin 2 receptor (CCK2R). It also stimulates the release of gastric acid in parietal cells via the CCK2R receptor. Gastrin plays a key role in Zollinger-Ellison syndrome. It may play a role in the development of colorectal carcinoma. |
| General description: | Gastrin, a classic digestive hormone, is found in three major forms: gastrin-34 (big gastrin), gastrin-17 (little gastrin), and gastrin-13 (minigastrin). Mammalian gastrin consists of a C-terminal four amino-acid sequence and a sulfated tyrosine 7 residue from the C-terminus. Gastrin is mostly found in the G cells of the stomach mucosa. Nutrients and gastrin-releasing peptides stimulate the release of gastrin. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥92% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |