Granzyme B Substrate
SIGMA/SCP0158
Empirical Formula (Hill Notation): C32H41N5O11
Molecular Weight: 671.69
Linear Formula: C32H41N5O11
Product Type: Chemical
assay | ≥95% (HPLC) |
composition | Peptide Content, ≥85% |
form | lyophilized |
storage condition | protect from light |
storage temp. | −20°C |
Amino Acid Sequence: | Ac-Ile-Glu-Pro-Asp-AMC |
Application: | Granzyme B Substrate (Ac-IEPD-AMC) is a fluorogenic substrate for the detection and assay of caspase 8 and granzyme B which is involved in the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. |
Biochem/physiol Actions: | Granzymes belongs to serine proteinase family enzymes and it localizes along with perforin in granules. It is predominant in cytotoxic T cells. Granzyme B induces caspases dependent and independent cell death. It possesses specific cleavage action at aspartate residue in the substrate. |
WGK Germany | - |
Purity | ≥95% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |