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MMP Substrate

SIGMA/SCP0193

Synonym: FS-6

Empirical Formula (Hill Notation): C55H80N16O16
Molecular Weight: 1221.32
Linear Formula: C55H80N16O16
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SCP0193-1MG 1 mg
 $205.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥95% (HPLC)
composition Peptide Content, ≥75%
form lyophilized
storage condition protect from light
storage temp. −20°C
Amino Acid Sequence: MCA-Lys-Pro-Leu-Gly-Leu-DNP-Dpa-Ala-Arg-NH2
Biochem/physiol Actions: Matrix Metalloproteases (MMPs) are involved in extracellular matrix (ECM) degradation. MMPs regulate cellular and disease processes. They are implicated in processes such as cell proliferation, migration, differentiation, angiogenesis, anti-inflammatory response, vasoconstriction, apoptosis and host defense. Dysregulation of MMP is associated with arthritis, ulcers, encephalomyelitis and cancer.
Biochem/physiol Actions: The peptide MCA-Lys-Pro-Leu-Gly-Leu-DNP-Dpa-Ala-Arg-NH2, or FS-6, is a fluorogenic substrate for several matrix metalloproteinases (MMPs). FS-6 is a water-soluble, modified form of the well-established MMP substrate FS-1, where a lysine residue has been added to the N-terminus of FS-1. The resulting FS-6 has been reported to give a peptide with improved kinetic properties for several MMPs, including MMP-1, MMP-8, MMP-13, and MMP-14, compared to FS-1. This MMP substrate has also been described as a particularly useful substrate for the zinc metalloproteinase tumor necrosis factor-α converting enzyme (TACE or ADAM-17). FS-6 can be used to measure metalloproteinase activity in tissue culture conditions, for example, on the surface of viable cells in situ.
General description: Matrix Metalloproteases (MMPs) belongs to the zinc metalloprotease family M10. They are zinc-dependent, calcium-containing hydrolases.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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