Synonym: 4,5-DCQA; 4,5-Di-O-caffeoylquinate; 4,5-Dicaffeoylquinic acid; Isochlorogenate C; Isochlorogenic acid C
CAS Number: 57378-72-0
Empirical Formula (Hill Notation): C25H24O12
Molecular Weight: 516.45
MDL Number: MFCD10566623
Linear Formula: C25H24O12
Product Type: Chemical
assay |
≥85% (LC/MS-ELSD) |
form |
solid |
InChI |
1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(35,24(33)34)11-19(30)23(20)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,35H,11-12H2,(H,33,34)/b7-3+,8-4+/t19-,20-,23+,25-/m1/s1 |
InChI key |
UFCLZKMFXSILNL-RVXRWRFUSA-N |
Quality Level |
200 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
SMILES string |
O[C@@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@H]1OC(=O)C=Cc3ccc(O)c(O)c3)C(O)=O |
storage temp. |
−20°C |
Application: |
4,5-Di-O-caffeoylquinic acid has been used as a reference standard to detect phenolic compounds from Artemisia species using high-performance liquid chromatography with diode array detection (HPLC-DAD) It has also been used as a standard in high-performance liquid chromatography with diode array detection (HPLC-DAD) respectively. |
Biochem/physiol Actions: |
4,5-Di-O-caffeoylquinic acid (4,5-COQ) is an excellent antioxidant, anti-inflammatory, antimicrobial, antifungal, and cytoprotective agent. It also shows neuroprotective and anti-amyloidogenic properties and can inhibit 42-mer amyloid β-protein (Aβ42). 4,5-COQ displays anti-human immunodeficiency virus (HIV) activity as its effectively inhibits HIV-1 reverse transcriptase. |
General description: |
4,5-Di-O-caffeoylquinic acid (4,5-COQ) is a derivative of caffeoylquinic acid which is a bioactive phenylpropanoid. |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥85% (LC/MS-ELSD) |
Storage Temp. |
−20°C |
UNSPSC |
12352200 |