Synonym: 1-C-(7-Amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-(1S)-D-Ribitol; 7-Amino-3-(β-D-ribofuranosyl)-1H-pyrazolo[4,3-d]pyrimidine; 8-Aza-9-deazaadenosine; Formycin; NSC 102811
CAS Number: 6742-12-7
Empirical Formula (Hill Notation): C10H13N5O4
Molecular Weight: 267.24
MDL Number: MFCD00036807
Linear Formula: C10H13N5O4
Product Type: Chemical
| antibiotic activity spectrum |
viruses (Antiretroviral) |
| assay |
≥98% (HPLC) |
| biological source |
Streptomyces kaniharaensis |
| color |
white to off-white |
| form |
powder |
| InChI |
1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 |
| InChI key |
OIRDTQYFTABQOQ-KQYNXXCUSA-N |
| mode of action |
enzyme | inhibits |
| Quality Level |
200  |
| SMILES string |
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O |
| solubility |
DMSO: soluble 1 mg/mL |
| |
H2O: soluble 3 mg/mL |
| storage condition |
(Keep container tightly closed in a dry and well-ventilated place.) |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
Formycin A (FA) is a C-nucleoside that inhibits the E.coli enzyme purine nucleoside phosphorylase (PNP). |
| Biochem/physiol Actions: |
Formycin A (FA) is a C-nucleoside that inhibits the E.coli enzyme purine nucleoside phosphorylase (PNP). FA was found to upsurge insulin release elevated by glucose, and was also shown to inhibit 5′-Methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase, an enzyme important in the recycling of methionine. Research has shown FA is an antiretroviral agent against HIV-1, targeting reverse transcription. |
| Biochem/physiol Actions: |
Formycin A possess antitumor function, along with its antibacterial and antiviral activity. |
| General description: |
Chemical structure: nucleoside |
| General description: |
Formycin A is an adenosine analog, and is cytotoxic in nature. It acts as a substrate for the human enzymes human erythrocytic adenosine deaminase and adenosine kinase. |
| Other Notes: |
Keep container tightly closed in a dry and well-ventilated place. |
| Other Notes: |
Store the product sealed at –20 °C. Under these conditions the product is stable for at least 4 years. |
| Packaging: |
10MG |
| Symbol |
 GHS07 |
| Signal word |
Warning |
| Hazard statements |
H302 |
| Hazard Codes |
Xn |
| Risk Statements |
22 |
| Safety Statements |
46 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
51102829 |
