Ruscogenin
SIGMA/SMB00295 - ≥98% (HPLC)
Synonym: (1β,3β,25R)-Spirost-5-ene-1,3-diol
CAS Number: 472-11-7
Empirical Formula (Hill Notation): C27H42O4
Molecular Weight: 430.62
MDL Number: MFCD00210550
Linear Formula: C27H42O4
Product Type: Chemical
| application(s) | metabolomics vitamins, nutraceuticals, and natural products |
| assay | ≥98% (HPLC) |
| form | powder |
| InChI | 1S/C27H42O4/c1-15-7-10-27 |
| InChI key | QMQIQBOGXYYATH-IDABPMKMSA |
| Quality Level | 200  |
| SMILES string | C[C@H](CC1)CO[C@]21O[C@@] |
| storage temp. | −20°C |
| Application: | Ruscogenin has been used to study its therapeutic effects on Crohn′s disease (CD)-like colitis both in vitro and in vivo studies. |
| Biochem/physiol Actions: | Ruscogenin is a well-known compound for down-regulating nuclear factor kappa B (NF-κB), intercellular adhesion molecule-1 (ICAM-1), tissue factor (TF), inducible NO synthase (iNOS), and modulating inflammatory pathways. It displays anti-inflammatory properties by inhibiting lipopolysaccharide (LPS)-induced acute lung injury (ALI), and improving diabetic nephropathy in in vivo studies. Ruscogenin also exerts neuroprotective properties and protects the brain against ischemic injury in mouse model. It elicits anti-tumor properties by inducing ferroptosis in pancreatic cancer cells in both in vitro and in vivo studies. |
| General description: | Ruscogenin is a major steroidal saponin found in the root of Ophiopogon japonicus. It was first isolated from Ruscus aculeatus. |
| Packaging: | 5 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352205 |