CDDO Methyl Ester

SIGMA/SMB00376 - ≥98% (HPLC)

Synonym: 2-Cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid methyl ester; Bardoxolone Methyl; CDDO-Me

CAS Number: 218600-53-4
Empirical Formula (Hill Notation): C₃₂H₄₃NO₄
Molecular Weight: 505.69
MDL Number: MFCD11983137
Linear Formula: C₃₂H₄₃NO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SMB00376-10MG	10 mg	$167.00 1/EA	Add To Favorites
45-SMB00376-100MG	100 mg	$571.00 1/EA	Add To Favorites

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This image depicts SKU: SMB00376-100MG

Properties
Descriptions
Safety Info.
Basic Data

application(s)	metabolomics vitamins, nutraceuticals, and natural products
assay	≥98% (HPLC)
form	powder
InChI	1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1
InChI key	WPTTVJLTNAWYAO-KPOXMGGZSA-N
Quality Level	200
SMILES string	CC1(C)CC[C@]2(C(OC)=O)CC[C@@]([C@@]3([H])[C@]2([H])C1)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(C(C#N)=C[C@]5(C)C4=CC3=O)=O
storage temp.	−20°C

Application:	CDDO Methyl Ester has been used to test its effect on hepatocyte membrane transporters (HMTs) regulation and mitigation of cholestasis in hepatic ischemia-reperfusion injury (IRI). It has also been used activator of NF E2 Related Factor 2 (NRF2) to study its role in preventing cell death in melanoma cells.
Biochem/physiol Actions:	CDDO-Me inhibits inflammatory mediators including interleukin-6 (IL-6), IL-10, and IL-12. It enhances apoptosis induced by TNF and chemotherapeutic agents. CDDO-Me exhibits anti-proliferative activity in osteosarcoma cells and enhances the effectiveness of chemotherapeutic agents by inducing an intrinsic mitochondrial-dependent apoptotic pathway. It can be used as an adjuvant treatment for advanced and fatal form of prostate cancer.
General description:	CDDO-Me is a synthetic triterpenoid compound with anti-inflammatory, anti-tumor and cytoprotective properties. It is derived from the natural product oleanic acid.
Packaging:	10 mg in glass bottle
Packaging:	100 mg in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352205

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