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CDDO Methyl Ester

SIGMA/SMB00376 - ≥98% (HPLC)

Synonym: 2-Cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid methyl ester; Bardoxolone Methyl; CDDO-Me

CAS Number: 218600-53-4
Empirical Formula (Hill Notation): C32H43NO4
Molecular Weight: 505.69
MDL Number: MFCD11983137
Linear Formula: C32H43NO4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SMB00376-10MG 10 mg
 $156.00
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45-SMB00376-100MG 100 mg
 $536.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: SMB00376-100MG

 

application(s) metabolomics
vitamins, nutraceuticals, and natural products
assay ≥98% (HPLC)
form powder
InChI 1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1
InChI key WPTTVJLTNAWYAO-KPOXMGGZSA-N
Quality Level 200 
SMILES string CC1(C)CC[C@]2(C(OC)=O)CC[C@@]([C@@]3([H])[C@]2([H])C1)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(C(C#N)=C[C@]5(C)C4=CC3=O)=O
storage temp. −20°C
Application: CDDO Methyl Ester has been used to test its effect on hepatocyte membrane transporters (HMTs) regulation and mitigation of cholestasis in hepatic ischemia-reperfusion injury (IRI). It has also been used activator of NF E2 Related Factor 2 (NRF2) to study its role in preventing cell death in melanoma cells.
Biochem/physiol Actions: CDDO-Me inhibits inflammatory mediators including interleukin-6 (IL-6), IL-10, and IL-12. It enhances apoptosis induced by TNF and chemotherapeutic agents. CDDO-Me exhibits anti-proliferative activity in osteosarcoma cells and enhances the effectiveness of chemotherapeutic agents by inducing an intrinsic mitochondrial-dependent apoptotic pathway. It can be used as an adjuvant treatment for advanced and fatal form of prostate cancer.
General description: CDDO-Me is a synthetic triterpenoid compound with anti-inflammatory, anti-tumor and cytoprotective properties. It is derived from the natural product oleanic acid.
Packaging: 10 mg in glass bottle
Packaging: 100 mg in poly bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352205

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