Prothionamide
SIGMA/SMB00387 - ≥99% (HPLC)
Synonym: Prothionamide; 2-
CAS Number: 14222-60-7
Empirical Formula (Hill Notation): C9H12N2S
Molecular Weight: 180.27
MDL Number: MFCD00464119
Linear Formula: C9H12N2S
Product Type: Chemical
antibiotic activity spectrum | mycobacteria |
assay | ≥99% (HPLC) |
color | yellow |
form | powder |
InChI | 1S/C9H12N2S/c1-2-3-8-6-7( |
InChI key | VRDIULHPQTYCLN-UHFFFAOYSA |
mode of action | enzyme | interferes |
Quality Level | 200 ![]() |
SMILES string | NC(C1=CC(CCC)=NC=C1)=S |
storage condition | (Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Non Combustible liquids.) |
storage temp. | −20°C |
Biochem/physiol Actions: | Prothionamide is the second line of drug used in leprosy and in tuberculosis. It is highly effective against Mycobacterium tuberculosis. In patients with multidrug-resistant tuberculosis (MDR-TB), prothionamide causes the development of hepatitis. In rare cases, it causes drug reaction with eosinophilia and systemic symptoms (DRESS) in patients with MDR-TB. DRESS is characterized by fever, hematologic abnormalities, skin eruption, and internal organ disruption. |
General description: | Chemical structure: pyridine |
General description: | Prothionamide is an analogue of ethionamide, and is better tolerated and less toxic than ethionamide. It contains a propyl group instead of an ethyl group at the α position. |
Other Notes: | Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids |
Packaging: | 1, 10 g in poly bottle |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H302 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥99% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 51101500 |