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Prothionamide

SIGMA/SMB00387 - ≥99% (HPLC)

Synonym: Prothionamide; 2-propyl-4-pyridinecarbothioamide; 2-propylisonicotinylthioamide; 2-propylthioisonicotinamide; 2-Propyl-4-pyridinecarbothioamide; 2-Propylisonicotinylthioamide

CAS Number: 14222-60-7
Empirical Formula (Hill Notation): C9H12N2S
Molecular Weight: 180.27
MDL Number: MFCD00464119
Linear Formula: C9H12N2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SMB00387-1G 1 g
 $93.70
1/EA		 Add To Favorites
45-SMB00387-10G 10 g
 $515.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: SMB00387-10G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: SMB00387-1G

 

antibiotic activity spectrum mycobacteria
assay ≥99% (HPLC)
color yellow
form powder
InChI 1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)
InChI key VRDIULHPQTYCLN-UHFFFAOYSA-N
mode of action enzyme | interferes
Quality Level 200 
SMILES string NC(C1=CC(CCC)=NC=C1)=S
storage temp. −20°C
Biochem/physiol Actions: Prothionamide is the second line of drug used in leprosy and in tuberculosis. It is highly effective against Mycobacterium tuberculosis. In patients with multidrug-resistant tuberculosis (MDR-TB), prothionamide causes the development of hepatitis. In rare cases, it causes drug reaction with eosinophilia and systemic symptoms (DRESS) in patients with MDR-TB. DRESS is characterized by fever, hematologic abnormalities, skin eruption, and internal organ disruption.
General description: Chemical structure: pyridine
General description: Prothionamide is an analogue of ethionamide, and is better tolerated and less toxic than ethionamide. It contains a propyl group instead of an ethyl group at the α position.
Other Notes: Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids
Packaging: 1, 10 g in poly bottle
Preparation Note: Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Non Combustible liquids.
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥99% (HPLC)
Storage Temp. −20°C
UNSPSC 51102829

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