Synonym: 2,4,3′,5′-tetramethoxystilbene; 1-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-2,4-dimethoxy-benzene; 2,3′,4,5′-Tetramethoxystilbene
CAS Number: 24144-92-1
Empirical Formula (Hill Notation): C18H20O4
Molecular Weight: 300.35
MDL Number: MFCD03428621
Linear Formula: C18H20O4
Product Type: Chemical
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This image depicts SKU: SMB00388-50MG
assay |
≥98% (HPLC) |
color |
white to yellow |
form |
powder |
InChI |
1S/C18H20O4/c1-19-15-8-7-14(18(12-15)22-4)6-5-13-9-16(20-2)11-17(10-13)21-3/h5-12H,1-4H3/b6-5+ |
InChI key |
JDBCWSHYEQUBLW-AATRIKPKSA-N |
Quality Level |
200 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
SMILES string |
COC1=CC(OC)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2 |
storage temp. |
−20°C |
technique(s) |
HPLC: suitable |
Biochem/physiol Actions: |
2,3′,4,5′-Tetramethoxystilbene, also known as TMS, is a selective and competitive inhibitor of cytochrome P450 1B. It is a synthetic trans-stilbene analog. TMS is an analog of resveratrol and is an anti-cancer agent. TMS is cytotoxic to gefitinib-resistant (G-R) non-small-cell lung cancer (NSCLC) cells. It binds to sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) and promotes apoptosis and autophagy. TMS is also a selective inhibitor of CYP1B1. |
Packaging: |
10 mg in glass bottle |
Packaging: |
50 mg in poly bottle |
Symbol |
GHS07 |
Signal word |
Warning |
Hazard statements |
H302 |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥98% (HPLC) |
Storage Temp. |
−20°C |
UNSPSC |
12352200 |