L-Theanine

SIGMA/SMB00395 - ≥98% (HPLC)

Synonym: N_γ-Ethyl-L-glutamine; L-Glutamic acid γ-(ethylamide); Suntheanine

CAS Number: 3081-61-6
Empirical Formula (Hill Notation): C₇H₁₄N₂O₃
Molecular Weight: 174.20
EC Number: 221-379-0
MDL Number: MFCD00059653
Linear Formula: C₇H₁₄N₂O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SMB00395-100MG	100 mg	$173.00 1/EA	Add To Favorites
45-SMB00395-500MG	500 mg	$676.00 1/EA	Add To Favorites

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This image depicts SKU: SMB00395-100MG

Properties
Descriptions
Safety Info.
Basic Data

application(s)	cell analysis
assay	≥98% (HPLC)
color	off-white
form	powder
InChI	1S/C7H14N2O3/c1-2-9-6(10)4-3-5(8)7(11)12/h5H,2-4,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
InChI key	DATAGRPVKZEWHA-YFKPBYRVSA-N
mp	217-218 °C
Quality Level	200
SMILES string	CCNC(=O)CC[C@H](N)C(O)=O
storage temp.	2-8°C

Application:	Safety and Efficacy of AlphaWave L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.: This clinical trial demonstrates that L-theanine supplementation effectively reduces stress and improves cognitive function without adverse effects (Moulin et al., 2024). (Moulin et al., 2024 ). Inhibitory Role of L-theanine, a Structural Analogue of Glutamate, Against GluR5 Kainate Receptor and its Prospective Utility Against Excitotoxicity.: The study examines L-theanine′s potential in protecting against neurotoxicity by inhibiting specific glutamate receptors (Deb and Borah, 2024). (Deb and Borah, 2024 ). L-theanine abates oxidative stress and mitochondrial dysfunction in myocardial ischemia-reperfusion injury by positively regulating the antioxidant response.: This research demonstrates the cardioprotective effects of L-theanine, highlighting its role in reducing oxidative stress and improving mitochondrial function during heart injuries (García-Niño et al., 2024). (García-Niño et al., 2024 ).
Biochem/physiol Actions:	L-Theanine modulates the activity of several antitumor drugs and has been reported to stimulate self-renewal of human embryonic stem cells. L-Theanine binds to AMPA, Kainate, NMDA, and group I mGlu receptors.
Biochem/physiol Actions:	Theanine is able to bind to AMPA, kainite, and NMDA glycine receptors in rat cortical neurons but with less affinity than glutamic acid. It has been studied as a glutamate transport inhibitor, preventing glutamate uptake by M5076 ovarian sarcoma-bearing mouse cells and increasing the effect of doxorubicin on tumor growth in M5076 mice.
General description:	L-Theanine is an analog of glutamine and a component of green tea.
Other Notes:	Theanine is an amino acid analog of glutamine, found in green tea.
Packaging:	100, 500 mg in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H317
Precautionary statements	P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
mp	217-218 °C
Storage Temp.	2-8°C
UNSPSC	12352209

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