Platycodin D
SIGMA/SMB00424 - ≥98% (HPLC)
Synonym: 3β-(β-D-glucopyranosyloxy)-2β,16α,23,24-tetrahydroxy-O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-olean-12-en-28-oic acid
CAS Number: 58479-68-8
Empirical Formula (Hill Notation): C57H92O28
Molecular Weight: 1225.32
Linear Formula: C57H92O28
Product Type: Chemical
application(s) | metabolomics vitamins, nutraceuticals, and natural products |
assay | ≥98% (HPLC) |
form | powder |
InChI | 1S/C57H92O28/c1-23-40(81- |
InChI key | RJDYKSRQTBCKLC-XTIQGCOGSA |
Quality Level | 200 |
SMILES string | O[C@@H]1[C@H](O[C@H]2[C@H |
storage temp. | 2-8°C |
Application: | Platycodin D has been used: • to test its anti-inflammatory and inhibitory effect on eosinophilic airway inflammation and T-helper type 2 (Th2) signaling pathways using ovalbumin (OVA)-induced allergic asthma mouse model • to test its anti-obese effects on the activation of brown adipose tissue featuring in vivo and in vitro studies • to test its efficacy as an adjuvant with infectious bronchitis (IB) vaccine in chicken |
Biochem/physiol Actions: | Platycodin D elicits strong anti-cancer properties and exhibits cytotoxicity against several cancer cell lines of both in vitro and in vivo origin. It exerts anti-inflammatory and protective effects against lipopolysaccharide (LPS)-induced acute lung injury (ALI) by upregulating liver-X receptors α (LXRα) and ATP-binding cassette transporter A1 (ABCA1) signaling pathway. It also possesses protective effects against Cisplatin (CDDP)-induced nephrotoxicity in mice. |
General description: | Platycodin D (PD) is a triterpenoid saponin found in the root of Platycodon grandifloras called Platycodonis Radix. |
Packaging: | 10 mg in glass bottle |
Packaging: | 50 mg in poly bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P301 + P312 + P330 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352205 |