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Ganoderic acid A

SIGMA/SMB00445 - ≥98% (HPLC)

Synonym: (2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid; (7β,15α,25R)-7,15-Dihydroxy-3,11,23-trioxo-lanost-8-en-26-oic acid

CAS Number: 81907-62-2
Empirical Formula (Hill Notation): C30H44O7
Molecular Weight: 516.67
Linear Formula: C30H44O7
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SMB00445-5MG 5 mg
 $407.00
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application(s) metabolomics
vitamins, nutraceuticals, and natural products
assay ≥98% (HPLC)
form powder
InChI 1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16?,18-,19+,21?,23+,28+,29-,30+/m1/s1
InChI key DYOKDAQBNHPJFD-ZQEHRSJRSA-N
Quality Level 200 
SMILES string OC(C(C)CC(C[C@@H](C)[C@H]1C[C@H](O)[C@@]([C@]1(C)CC2=O)(C)C3=C2[C@]4(C)C(C[C@@H]3O)C(C)(C)C(CC4)=O)=O)=O
storage temp. −20°C
Application: Ganoderic acid A has been used:
• to study its protective effects on hypoxia-induced rat cardiomyocytes (H9c2) cell injury
• as a reference standard to study its inhibitory and antiviral effects against groundnut bud necrosis virus (GBNV) infection in cowpea plants
• as a standard in Fourier transformed-infrared (FT-IR) spectroscopy for the analysis of secondary metabolites from Ganoderma lucidum
Biochem/physiol Actions: Ganoderic Acid A (GAA) improves lipid metabolism, gut microbiota composition, and hyperlipidemia in high-fat-diet (HFD)-fed mice. It is proven to be a potential therapeutic anticancer agent in several in vitro studies by suppressing cell proliferation in different cancer cells such as breast cancer, human hepatocellular carcinoma cells, and osteosarcoma. GAA displays neuroprotective activities against depression-like behaviors, inflammation, and neuronal damage in the post-stroke depression (PSD) rat model. It also displays anti-human immunodeficiency virus (HIV) activity.
General description: Ganoderic Acid A or GAA is one of the most abundant triterpenoids that is found in Ganoderma lucidum fungi. The chemical structure of GAA has a tetracyclic ring with a double bond and terminal carboxyl group on the branch.
Packaging: 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352205

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