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Dioscin

SIGMA/SMB00576 - ≥95% (HPLC)

Synonym: Collettiside III; Diosgenin bis-α-L-rhamnopyranosyl-(1→2,1→4)-beta-D-glucopyranoside; Polyphyllin III

CAS Number: 19057-60-4
Empirical Formula (Hill Notation): C45H72O16
Molecular Weight: 869.04
MDL Number: MFCD02094174
Linear Formula: C45H72O16
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SMB00576-25MG 25 mg
 $447.00
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assay ≥95% (HPLC)
form powder
InChI 1S/C45H72O16/c1-19-9-14-45(54-18-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(52)34(50)32(48)22(4)56-41)37(53)38(29(17-46)58-42)59-40-35(51)33(49)31(47)21(3)55-40/h7,19-22,24-42,46-53H,8-18H2,1-6H3/t19-,20+,21+,22+,24+,25-,26+,27+,28+,29-,30+,31+,32+,33-,34-,35-,36-,37+,38-,39-,40+,41+,42-,43+,44+,45-/m1/s1
InChI key VNONINPVFQTJOC-ZGXDEBHDSA-N
Quality Level 200 
SMILES string C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@@H](C)CO4)([H])C[C@@]1([H])[C@@](CC=C5[C@@]6(CC[C@H](O[C@@](O[C@H](CO)[C@@H](O[C@@](O[C@@H](C)[C@H](O)[C@H]7O)([H])[C@@H]7O)[C@@H]8O)([H])[C@@H]8O[C@@](O[C@@H](C)[C@H](O)[C@H]9O)([H])[C@@H]9O)C5)C)([H])[C@]6([H]
storage temp. 2-8°C
Application: Dioscin has been used to study its anti-inflammatory and protective effects on neuron damage due to ischemia‑reperfusion injury (IRI). It has also been used as a commercial saponin to perform a comparative analysis and study its permeabilization power in respirometry technique.
Biochem/physiol Actions: Dioscin is a potent anti-tumor agent and elicits strong anti-cancer properties against several cancers like breast, renal, lung, and liver cancers, gastric carcinoma, acute myeloid leukemia. It displays hepatoprotective, cardioprotective, and nephroprotective properties. Dioscin also exerts anti-diabetic, antifungal, and antiviral effects.
General description: Dioscin is a highly fat-soluble steroid saponin found in many varieties of Dioscoreaceae plants including Dioscorea nipponica Makino.
Packaging: 25 mg in poly bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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