Diallyl trisulfide
SIGMA/SMB00577 - ≥97% (HPLC)
Synonym: Allyl trisulfide; Di-2-propenyl trisulfide
CAS Number: 2050-87-5
Empirical Formula (Hill Notation): C6H10S3
Molecular Weight: 178.34
EC Number: 218-107-8
MDL Number: MFCD00040025
Linear Formula: C6H10S3
Product Type: Chemical
| application(s) | metabolomics vitamins, nutraceuticals, and natural products |
| assay | ≥97% (HPLC) |
| biological source | Allium sativum L. |
| form | liquid |
| InChI | 1S/C6H10S3/c1-3-5-7-9-8-6 |
| InChI key | UBAXRAHSPKWNCX-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | C=CCSSSCC=C |
| storage temp. | −20°C |
| Application: | Diallyl trisulfide (DATS) has been used as an exogenous hydrogen sulfide (H2S)donor to study the effects on proliferation, apoptosis, and autophagy of human urothelial carcinoma (UC) cells in vitro. |
| Biochem/physiol Actions: | Diallyl trisulfide elicits cardioprotective and anti-metabolic syndrome (MetS) effects against ex vivo induced myocardial ischemia/reperfusion (I/R) injury in MetS rats (male Wistar albino). It is a potent anti-cancer agent and acts by modulating different cancer-related pathways, inducing cell cycle arrest, apoptosis, metastasis, and angiogenesis in in vitro studies. DATS is also an effective therapeutic agent against multidrug resistance in triple-negative breast cancer (TNBC). DATS and its nanoemulsions display high antifungal activity against wood-rotting fungi such as T. hirsuta and L. sulphureus. It also provides protection against brain damage induced by ischemia/reperfusion (I/R) by activating nuclear factor erythroid 2-related factor 2 (Nrf2) in rat brains. |
| General description: | Diallyl trisulfide (DATS) is one of the stable naturally occurring bioactive polysulfide compounds found in Allium vegetables, especially in garlic. |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P310 + P330 |
| RIDADR | UN 2810 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |