Nimbolide
SIGMA/SMB00586 - from Azadirachta indica, ≥98%
Synonym: NSC-309909
CAS Number: 25990-37-8
Empirical Formula (Hill Notation): C27H30O7
Molecular Weight: 466.52
Linear Formula: C27H30O7
Product Type: Chemical
assay | ≥98% |
form | powder |
InChI | 1S/C27H30O7/c1-13-15(14-7 |
InChI key | JZIQWNPPBKFOPT-LSYMHUITSA |
Quality Level | 200 ![]() |
SMILES string | [H][C@@]12C[C@@H](C3=COC= |
storage temp. | −20°C |
Biochem/physiol Actions: | Nimbolide exhibits anti-malarial, anti-bacterial, and anti-cancer activities. It has been shown to induce apoptosis in osteosarcoma cells and inhibits cell migration of these cells by modulating the expression of integrin αvβ5. In human renal carcinoma cells, nimbolide induced cell cycle arrest, DNA damage, and apoptosis.It has been shown to modulate autophagy and apoptosis in pancreatic cancer. |
General description: | Nimbolide is a limonoid tetranortriterpenoid with an α,β-unsaturated ketone system and a δ-lactone ring. It is usually isolated from Azadirachta indica (Neem). |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P301 + P312 + P330 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% |
Storage Temp. | −20°C |
UNSPSC | 12352200 |