Nimbolide
SIGMA/SMB00586 - from Azadirachta indica, ≥98%
Synonym: NSC-309909
CAS Number: 25990-37-8
Empirical Formula (Hill Notation): C27H30O7
Molecular Weight: 466.52
Linear Formula: C27H30O7
Product Type: Chemical
| application(s) | metabolomics vitamins, nutraceuticals, and natural products |
| assay | ≥98% |
| form | powder |
| InChI | 1S/C27H30O7/c1-13-15(14-7 |
| InChI key | JZIQWNPPBKFOPT-LSYMHUITSA |
| Quality Level | 200  |
| SMILES string | [H][C@@]12C[C@@H](C3=COC= |
| storage temp. | −20°C |
| Application: | Nimbolide has been used as an anticancer agent to study its effects on the proliferation, migration, and invasion of human bladder cancer cell lines (EJ and 5637). It has also been used as a treatment to target RNF114 and trap PARP1 inhibitor(PARPi) and PARylation-dependent DNA repair factors. |
| Biochem/physiol Actions: | Nimbolide exhibits anti-malarial, anti-bacterial, and anti-cancer activities. It has been shown to induce apoptosis in osteosarcoma cells and inhibits cell migration of these cells by modulating the expression of integrin αvβ5. In human renal carcinoma cells, nimbolide induced cell cycle arrest, DNA damage, and apoptosis.It has been shown to modulate autophagy and apoptosis in pancreatic cancer. |
| General description: | Nimbolide is a limonoid tetranortriterpenoid with an α,β-unsaturated ketone system, and a δ-lactone ring. It is usually isolated from Azadirachta indica (Neem). |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% |
| Storage Temp. | −20°C |
| UNSPSC | 12352205 |