Dirithromycin
SIGMA/SMB00606 - ≥96%
Synonym: [9S(R)
CAS Number: 62013-04-1
Empirical Formula (Hill Notation): C42H78N2O14
Molecular Weight: 835.07
MDL Number: MFCD00865041
Linear Formula: C42H78N2O14
Product Type: Chemical
| antibiotic activity spectrum | Gram-negative bacteria |
| assay | ≥96% |
| color | white to off-white |
| form | powder |
| InChI | 1S/C42H78N2O14/c1-15-29-4 |
| InChI key | WLOHNSSYAXHWNR-KZYCBHIHSA |
| mode of action | protein synthesis | interferes |
| Quality Level | 200  |
| SMILES string | CC[C@H]1OC(=O)[C@H](C)[C@ |
| storage condition | (Keep container tightly closed in a dry and well-ventilated place.) |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | Dirithromycin is a macrolide antibiotic. It is a prodrug of erythromycylamine that has outstanding activity against Campylobacter. Dirithromycin is a group 3 agent with respect to its interaction with cytochrome P450 (CYP) isoform 3A4, as it interferes poorly with CYP3A4 in vitro and generally does not alter drug metabolism in vivo. |
| Other Notes: | Keep container tightly closed in a dry and well-ventilated place. |
| Packaging: | 1G |
| Preparation Note: | When dissolving dirithromycin in organic solvents, first purge the solvent with inert gas. To prepare in aqueous buffer, dirithromycin should first be dissolved in ethanol and then diluted with aqueous buffer. The solution is stable for one day. Dirithromycin is soluble in ethanol at approximately 20 mg/mL, DMF at approximately 10 mg/mL, and DMSO at approximately 15 mg/mL. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P280 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥96% |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |