Amoxicillin trihydrate: potassium clavulanate (4:1)
SIGMA/SMB00607
Synonym: Amoxicillin Trihydrate: Potassium Clavulanate
Product Type: Chemical
| antibiotic activity spectrum | Gram-negative bacteria |
| Gram-positive bacteria | |
| color | off-white |
| form | powder |
| mode of action | cell wall synthesis | interferes |
| Quality Level | 200  |
| solubility | water: 1 mg/mL |
| storage condition | (Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.) |
| storage temp. | 2-8°C |
| Application: | Amoxicillin trihydrate: potassium clavulanate (4:1) has been used to study its effect on the viral déjà vu disease (neonatal intracerebral (i.c.) infection) in mice model. |
| Biochem/physiol Actions: | Amoxicillin trihydrate is a broad-spectrum, β-lactam antibiotic. It inhibits the cross-linkage between linear peptidoglycan polymer chains that are the major component of both Gram-positive and Gram-negative bacteria. Since amoxicillin is degraded by β-lactamases, it does not show activity against bacteria which produce these enzymes. Clavulanate is a β-lactam antibiotic related to the penicillins. Clavulanate competitively and irreversibly inhibits a wide variety of β-lactamases found in bacteria that are resistant to penicillins and cephalosporins. Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin′s antibacterial activity against bacteria normally resistant to β-lactam antibiotics. |
| Components: | Material is a powdered mixture of 4 parts amoxicillin trihydrate to 1 part potassium clavulanate. |
| General description: | Amoxicillin trihydrate is a semisynthetic antibiotic, that is used as a medicine. |
| Other Notes: | Keep container tightly closed in a dry and well-ventilated place. Never allow product to get in contact with water during storage. |
| Packaging: | 1G |
| Symbol |   GHS02,GHS08 |
| Signal word | Danger |
| Hazard statements | H228 - H252 - H317 - H334 |
| Precautionary statements | P210 - P235 - P240 - P241 - P280 - P302 + P352 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Supplemental Hazard Statements | EUH014 - EUH044 |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |