6,6′-Dihydroxythiobinupharidine
SIGMA/SMB00609 - ≥95% (HPLC)
Synonym: 6,6′-Dihydroxythionuphlutine A; Nuphleine
CAS Number: 30343-70-5
Empirical Formula (Hill Notation): C30H42N2O4S
Molecular Weight: 526.73
Linear Formula: C30H42N2O4S
Product Type: Chemical
antibiotic activity spectrum | Gram-positive bacteria |
assay | ≥95% (HPLC) |
form | powder |
mode of action | enzyme | inhibits |
Quality Level | 200 |
SMILES string | O[C@H]1N2[C@@]([C@H](C)CC |
storage temp. | −20°C |
Biochem/physiol Actions: | 6,6′-Dihydroxythiobinupha It was also found to act synergistically with cytotoxic drugs such as cisplatin and etoposide, enabling their cytotoxic effect at lower concentrations. 6,6′-Dihydroxythiobinupha In addition, Nuphar lutea extract was effective against both Leishmania promastigote and amastigote forms (IC50 = 2 ± 0.12 μg/mL; ID50 = 0.65 ± 0.023 μg/mL; LD50 = 2.1 ± 0.096 μg/mL, STI = 3.23). A synergistic antileishmanial activity was demonstrated with the antileishmanial drug, paromomycin. Recently 6,6′-dihydroxythiobinupharidine was found to be active against MRSA and VRE strains with an MIC of 1-4 μg/mL. Inhibition of DNA topoisomerase IV but not DNA gyrase in S. aureus was suggested as the mechanism of action. 6,6′-Dihydroxythiobinupha |
General description: | 6,6′-Dihydroxythiobinupha |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |