Lysobactin
SIGMA/SMB00708 - ≥97% (HPLC)
Synonym: Katanosin B; L-Serine, D-leucyl-L-leucyl-(βR)-β-hydroxy-L-phenylalanyl-(3R)-3-hydroxy-L-leucyl-L-leucyl-D-arginyl-L-isoleucyl-L-allothreonylglycyl-(3S)-3-hydroxy-L-asparaginyl-, (11→3)-lactone
CAS Number: 118374-47-3 (free base)
Empirical Formula (Hill Notation): C58H97N15O17 · xC2H4O2
Molecular Weight: 1276.48 (free base basis)
Linear Formula: C58H97N15O17 · xC2H4O2
Product Type: Chemical
| antibiotic activity spectrum | Gram-negative bacteria |
| Gram-positive bacteria | |
| assay | ≥97% (HPLC) |
| composition | counterion (acetate salt) |
| form | powder |
| mode of action | cell wall synthesis | interferes |
| Quality Level | 200  |
| solubility | DMSO: 1 mg/mL |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Lysobactin is a cyclic peptide with strong antibacterial activity against many bacterial strains including Staphylococcus aureus, Salmonella typhosa, and Klebsiella aerogenes. Lysobactin is reported to have MIC values of 0.2, 25, and 25 μg/mL for the above listed bacteria respectively, which is significantly higher than the potency reported for vancomycin for the same bacteria (MIC values 0.8, >100, and >100 μg/mL respectively). The mechanism of action of lysobactin is attributed to its interaction with lipid I and lipid II in the bacterial cell wall. Lysobactin forms a 1:1 complex with lipid I and lipid II causing interference in peptidoglycan synthesis which is essential for bacterial viability. Furthermore, lysobactin was not found to be hemolytic at concentrations above its MIC. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |