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Bavachin

SIGMA/SMB00802 - from Psoralea coryfolia, ≥97% (HPLC)

Synonym: (2S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one; 4′,7-Dihydroxy 6-(3-methyl 2-butenyl)flavanone; Corylifolin

CAS Number: 19879-32-4
Empirical Formula (Hill Notation): C20H20O4
Molecular Weight: 324.37
MDL Number: MFCD11617359
Linear Formula: C20H20O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SMB00802-5MG 5 mg
 $163.00
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application(s) metabolomics
vitamins, nutraceuticals, and natural products
assay ≥97% (HPLC)
form powder
InChI 1S/C20H20O4/c1-12(2)3-4-14-9-16-18(23)11-19(24-20(16)10-17(14)22)13-5-7-15(21)8-6-13/h3,5-10,19,21-22H,4,11H2,1-2H3
InChI key OAUREGNZECGNQS-UHFFFAOYSA-N
SMILES string O1C(CC(=O)c3c1cc(c(c3)CC=C(C)C)O)c2ccc(cc2)O
storage temp. −20°C
Biochem/physiol Actions: Bavachin is a flavonoid isolated from seeds of Psoralea corylifolia. It is a phytoestrogen that activates ERα and ERβ (EC50s = 320 and 680 nM, respectively), stimulates osteoblast proliferation and differentiation, and prevents bone loss following ovariectomy in rats.

Bavachin is an inhibitor of acyl coenzyme A: cholesterol acyltransferase (ACAT). The IC50 value of bavachin was reported to be 86.0 μM in ACAT assay system using rat liver microsome.

Bavachin is also reported to increase insulin-induced glucose uptake by differentiated adipocytes and myoblasts.
General description: Bavachin is soluble in DMSO at 30 mg/mL. Bavachin is not water soluble.
Purity ≥97% (HPLC)
Storage Temp. −20°C
UNSPSC 12352205

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