Oleocanthal
SIGMA/SMB00810 - from Olea europaea
Synonym: (-)-Oleocanthal
CAS Number: 289030-99-5
Empirical Formula (Hill Notation): C17H20O5
Molecular Weight: 304.34
Linear Formula: C17H20O5
Product Type: Chemical
| assay | ≥95% |
| biological source | Olea europaea |
| form | film |
| shipped in | dry ice |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Oleocanthal is one of the important polyphenols of olive oil well-known for its biological properties and health benefits. It exerts anti-inflammatory activity due to its dose-dependent inhibition of cyclooxygenase (COX-1, COX-2) enzymes in the prostaglandin biosynthesis in the same pathway as Ibuprofen. Oleocanthal is a potent anti-cancer agent, its treatment demonstrates inhibition of proliferation, migration, and invasion of various human breast cancer, prostate cancer, and multiple myeloma cells. In non-melanoma skin cancer, it reduces cell viability and migration, through inhibition of Erk and Akt phosphorylation and suppression of B-Raf expression. Oleocanthal was found to modulate estrogen receptor expression in luminal breast cancer and acts synergistically with tamoxifen treatment. It also elicits neuroprotective properties by inhibiting the formation of neurofibrillary tangles, a key hallmark in the pathogenesis of Alzheimer′s disease. Oleocanthal has also been reported to increase Amyloid-β transport across the blood-brain barrier via P-glycoprotein induction. It was found that it acts synergistically with Donepezil, an acetylcholine esterase inhibitor approved for use for all Alzheimer′s disease stages. Oleuropein displays anti-leishmanial activity when added in vitro and in vivo, in experimental models of Leishmania infection. |
| General description: | Oleocanthal is a naturally occurring secoiridoid from olive oil. It is one of olive oil′s minor constituents, making only 10% of its polyphenols. |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |