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C646

SIGMA/SML0002 - ≥98% (HPLC)

Synonym: 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid

CAS Number: 328968-36-1
Empirical Formula (Hill Notation): C24H19N3O6
Molecular Weight: 445.42
MDL Number: MFCD01784780
Linear Formula: C24H19N3O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0002-5MG 5 mg
 $168.00
1/EA		 Add To Favorites
45-SML0002-25MG 25 mg
 $677.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color red to brown
form powder
InChI 1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-
InChI key HEKJYZZSCQBJGB-UNOMPAQXSA-N
Quality Level 100 
SMILES string Cc1cc(-c2ccc(C=C3C(C)=NN(c4ccc(cc4)C(O)=O)C3=O)o2)c(cc1C)[N+]([O-])=O
solubility DMSO: >25 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: C646 was used to study the role of p300 in chronic neuropathic pain in rats with chronic constriction injury.
Biochem/physiol Actions: C646 is a competitive histone acetyltransferase (HAT) p300/CBP inhibitor with a Ki of 400 nM and is selective versus other acetyltransferases.
Biochem/physiol Actions: C646 is a potent, cell permeable and selective inhibitor of p300 and CBP (p300/CBP) histone acetyltransferases. Inhibition of p300/CBP by C646 affects the activity of a variety of transcriptional factors such as NF-κB, p53 and MyoD that are associated with physiology, disease processes, hippocampal synaptic plasticity, spatial memory and contextual fear.
Biochem/physiol Actions: C646 is a potent, competitive, and selective histone acetyltransferase (HAT) p300/CBP inhibitor.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Hazard Codes N
Risk Statements 50
Safety Statements 61
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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