Synonym: 2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one; 7-Hydroxy-2,3,4,5-tetrahydro-1H-benzofuro[2,3-c]azepin-1-one
CAS Number: 521937-07-5
Empirical Formula (Hill Notation): C12H11NO3
Molecular Weight: 217.22
MDL Number: MFCD03828155
Linear Formula: C12H11NO3
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to tan |
| form |
powder |
| InChI |
1S/C12H11NO3/c14-7-3-4-10-9(6-7)8-2-1-5-13-12(15)11(8)16-10/h3-4,6,14H,1-2,5H2,(H,13,15) |
| InChI key |
AACFPJSJOWQNBN-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
Oc1ccc2oc3C(=O)NCCCc3c2c1 |
| solubility |
DMSO: ≥15 mg/mL |
| storage temp. |
2-8°C |
| Application: |
CID755673 was used to study the role of PKD in dendrite retraction in mouse Purkinje cells. |
| Biochem/physiol Actions: |
CID755673 is a cell-permeable, potent and selective inhibitor of all three protein kinase D (PKD) isoforms PKD1 (PKCμ), PKD2, and PKD3 (PKCν). CID755673 is not competitive with ATP. |
| Biochem/physiol Actions: |
CID755673 is a cell-permeable, potent and selective inhibitor of all three protein kinase D (PKD) isoforms PKD1(PKCμ), PKD2, and PKD3 (PKCν). |
| Biochem/physiol Actions: |
CID755673 was not suitable to inhibit PKD in Swiss 3T3 cells as it utilizes PKD-dependent pathway to enhance the mitogenic signaling triggered by EGF, phorbol esters and bombesin. It should, therefore, be used with caution. |
| Features and Benefits: |
This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: |
5, 25 mg in glass bottle |
| Hazard Codes |
Xn |
| Risk Statements |
22-36 |
| Safety Statements |
26 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
