Cerivastatin sodium salt hydrate

SIGMA/SML0005 - ≥98% (HPLC)

Synonym: (3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate; Rivastatin hydrate

CAS Number: 143201-11-0 (anhydrous)
Empirical Formula (Hill Notation): C₂₆H₃₃FNNaO₅ · xH₂O
Molecular Weight: 481.53 (anhydrous basis)
MDL Number: MFCD20488047
Linear Formula: C₂₆H₃₃FNNaO₅ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0005-5MG	5 mg	$178.00 1/EA	Add To Favorites
45-SML0005-25MG	25 mg	$712.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0005-25MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to tan
form	powder
InChI	1S/C26H34FNO5.Na.H2O/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4;;/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32);;1H2/q;+1;/p-1/b11-10+;;/t19-,20-;;/m1../s1
InChI key	NJHMEKXCHXHQPP-PZLZTSNUSA-M
optical activity	[α]/D +18 to +26° in ethanol
originator	Bayer
Quality Level	100
SMILES string	O.[Na+].COCc1c(nc(C(C)C)c(C=C[C@@H](O)C[C@@H](O)CC([O-])=O)c1-c2ccc(F)cc2)C(C)C
solubility	H₂O: ≥5 mg/mL
storage condition	desiccated
storage temp.	2-8°C

Application:	Cerivastatin sodium salt hydrate has been used as a supplement in cell culture.
Application:	Cerivastatin sodium salt hydrate may be used in cell signaling studies.
Biochem/physiol Actions:	Accumulated macrophages in atherosclerotic plaques result in plaque rupture and thrombus formation. Cerivastatin suppresses the growth of macrophages and decreases the expression of matrix metalloproteinases and tissue factor molecules, thus reduces acute coronary events.
Biochem/physiol Actions:	Cerivastatin sodium is an HMG-CoA reductase inhibitor. HMG-CoA is a key enzyme in the production of cholesterol.
Biochem/physiol Actions:	HMG-CoA reductase inhibitor
Features and Benefits:	This compound was developed by Bayer . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	Cerivastatin sodium salt hydrate belongs to the statin class of lipid lowering agents. It helps in decreasing MAP kinase activation, blocking AP-1 (activator protein-1) and NF-kB (nuclear factor-kB ) binding activity, inhibiting inflammatory responses and ameliorated renal damage. It also lowers cholesterol. It is metabolized by cytochrome P450 (CYP)3A4 and (CYP)2C8. Cerivastatin sodium salt hydrate is linked to rhabdomyolysis.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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