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Cevimeline hydrochloride hemihydrate

SIGMA/SML0007 - ≥95% (HPLC, NMR)

Synonym: AF-102B; SNI-2011

CAS Number: 153504-70-2
Empirical Formula (Hill Notation): C10H17NOS · xHCl · yH2O
Molecular Weight: 199.31 (anhydrous free base basis)
Linear Formula: C10H17NOS · xHCl · yH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0007-5MG 5 mg
 $163.00
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45-SML0007-25MG 25 mg
 $623.00
1/EA		 Add To Favorites

 

assay ≥95% (HPLC, NMR)
color white to tan
form powder
InChI 1S/2C10H17NOS.2ClH.H2O/c2*1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;;;/h2*8-9H,2-7H2,1H3;2*1H;1H2/t2*8-,10-;;;/m11.../s1
InChI key ZSTLCHCDLIUXJE-GMLJRNIPSA-N
originator Daiichi-Sankyo
Quality Level 100 
shipped in wet ice
SMILES string O.Cl.Cl.C[C@@H]1O[C@@]2(CS1)CN3CC[C@H]2CC3.C[C@@H]4O[C@@]5(CS4)CN6CC[C@H]5CC6
solubility H2O: ≥25 mg/mL
storage condition desiccated
storage temp. −20°C
Application: Cevimeline hydrochloride hemihydrate may be used in cell signaling studies.
Biochem/physiol Actions: Cevimeline is a muscarinic M1 and M3 receptor agonist.
Biochem/physiol Actions: Cevimeline is a muscarinic M1 and M3 receptor agonist. Cevimeline stimulates secretion by the salivary glands and is used to treat the symptoms of dry mouth.
Biochem/physiol Actions: Cevimeline stimulates the peripheral muscarinic acetylcholine receptors of salivary glands and increases the concentration of Ca+2 in parotic acini and duct cells of rats. It thus acts as therapeutic agent for xerostomia.
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Acetylcholine Receptors (Muscarinic)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Daiichi-Sankyo . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P310
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC, NMR)
Storage Temp. −20°C
UNSPSC 12352200

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