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SR 142948A

SIGMA/SML0015 - ≥98% (HPLC)

Synonym: 2-[[5-(2,6-dimethoxyphenyl)-1-(4-(N-(3-dimethylaminopropyl)-N-methylcarbamoyl)-2-isopropylphenyl)-1H-pyrazole3-carbonyl]amino] adamantane-2-carboxylic acid hydrochloride; SR 142948 hydrochloride

CAS Number: 184162-21-8
Empirical Formula (Hill Notation): C39H51N5O6·HCl
Molecular Weight: 722.31
MDL Number: MFCD03106502
Linear Formula: C39H51N5O6·HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0015-5MG 5 mg
 $210.00
1/EA		 Add To Favorites
45-SML0015-25MG 25 mg
 $830.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C39H51N5O6.ClH/c1-23(2)29-21-26(37(46)43(5)15-9-14-42(3)4)12-13-31(29)44-32(35-33(49-6)10-8-11-34(35)50-7)22-30(41-44)36(45)40-39(38(47)48)27-17-24-16-25(19-27)20-28(39)18-24;/h8,10-13,21-25,27-28H,9,14-20H2,1-7H3,(H,40,45)(H,47,48);1H/t24-,25+,27-,28+,39?;
InChI key CUYNEHGBVHUQQW-BVJGGMLGSA-N
originator Sanofi Aventis
Quality Level 100 
SMILES string Cl.COc1cccc(OC)c1-c2cc(nn2-c3ccc(cc3C(C)C)C(=O)N(C)CCCN(C)C)C(=O)NC4([C@@H]5C[C@H]6C[C@@H](C5)C[C@@H]4C6)C(O)=O
solubility H2O: ≥2 mg/mL at warmed to 60 °C
storage temp. 2-8°C
Application: SR 142948A was used to study the role of neurotensin signaling in intracellular alkanization and expression of IL-8 in human pancreatic cancer cells.
Biochem/physiol Actions: SR 142948A is a neurotensin receptor antagonist
Biochem/physiol Actions: SR 142948A is a non-peptide Neurotensin receptor antagonist
Biochem/physiol Actions: SR 142948A is a potent neurotensin receptor antagonist that affects the expression of c-Fos and has properties of antipsychotic agent. It blocks hypothermia and analgesia induced by neurotensin. It blocks the increase in the concentration of Ca+2 induced by the activation of phospholipase C in CHO cell model.
Features and Benefits: This compound is featured on the Neurotensin Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Sanofi Aventis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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