CCG-63802
SIGMA/SML0016
Synonym: α-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile
CAS Number: 620112-78-9
Empirical Formula (Hill Notation): C26H18N4O2S
Molecular Weight: 450.51
Linear Formula: C26H18N4O2S
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | yellow |
| form | powder |
| Quality Level | 100  |
| solubility | DMSO: ≥5 mg/mL (;warmed DMSO) |
| storage temp. | room temp |
| Application: | CCG-63802 may be used to study G-protein-mediated cell signaling. |
| Biochem/physiol Actions: | CCG-63802 is a reversible, allosteric inhibitor of RGS4 |
| Biochem/physiol Actions: | GCC-63802 binds to RGS4 and blocks interaction with Goa (IC50 = 1.9 uM). RGS4 (Regulator of G protein Signaling) is one of the RGP proteins responsible for terminating mu opioid receptor signaling. RSG proteins are GTPase activators, and drive G protein subunits to an inactive, GDP-bound form. |
| Features and Benefits: | This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the G Proteins (Heterotrimeric) and Opioid Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |