BX471
SIGMA/SML0020 - ≥98% (HPLC)
Synonym: N-
CAS Number: 217645-70-0 (free acid)
Empirical Formula (Hill Notation): C21H24ClFN4O3
Molecular Weight: 434.89
Linear Formula: C21H24ClFN4O3
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to tan |
| form | powder |
| InChI | 1S/C21H24ClFN4O3/c1-14-11 |
| InChI key | XQYASZNUFDVMFH-CQSZACIVSA |
| originator | Bayer |
| Quality Level | 100  |
| SMILES string | Fc1ccc(cc1)CN2C[C@H](N(CC |
| solubility | DMSO: ≥25 mg/mL |
| storage condition | desiccated |
| storage temp. | 2-8°C |
| Application: | BX471 has been used in chemotaxis assay to study the responses of HEK293 cells expressing human C-C motif chemokine receptor 1 (CCR1) to CC motif ligand 3 (CCL3)-induced cell migration. It has also been used as a CCR1 inhibitor to assess the effects of CCR1 on the migration and epithelial-mesenchymal transition (EMT). |
| Biochem/physiol Actions: | BX471 blocks CCR1 and downregulates the mRNA expression of ICAM-1, P-selectin and E-selectin. It decreases the inflammatory responses in sepsis, prevents monocyte recruitment in inflammation sites in rheumatoid arthritis patients and inhibits interstitial leukocyte recruitment and fibrosis in mouse model of lupus nephritis. |
| Biochem/physiol Actions: | BX471 is a CCR1 Antagonist |
| Biochem/physiol Actions: | BX471 is an orally active, CCR-1 specific antagonist. It displaces the endogenous CCR-1 ligands MIP-1a, RANTES and MCP-3 (Ki range 1-5 nM). BX471 inhibits CCR-1 effects in leukocytes, including calcium mobilization and migration. |
| Features and Benefits: | This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by Bayer . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | Xn,N |
| Risk Statements | 22-50 |
| Safety Statements | 61 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 51111800 |