Synonym: 2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid methyl ester; Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate
CAS Number: 922507-80-0
Empirical Formula (Hill Notation): C16H17ClN2O3
Molecular Weight: 320.77
MDL Number: MFCD20134198
Linear Formula: C16H17ClN2O3
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to tan |
| form |
powder |
| InChI |
1S/C16H17ClN2O3/c1-16(15(21)22-2)14-11(7-8-19(16)13(20)9-17)10-5-3-4-6-12(10)18-14/h3-6,18H,7-9H2,1-2H3 |
| InChI key |
BCSIRYFYAKLJDK-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
COC(=O)C1(C)N(CCc2c1[nH]c3ccccc23)C(=O)CCl |
| solubility |
DMSO: 12 mg/mL, clear |
| storage temp. |
2-8°C |
| Application: |
PDI inhibitor 16F16 has been used to inhibit PDI (protein disulfide isomerase) function to examine the functional conservation of PDIs in human embryonic kidney cells. |
| Application: |
PDI inhibitor 16F16 may be used in protein disulfide isomerase-mediated cell signaling studies. |
| Biochem/physiol Actions: |
16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation. |
| Biochem/physiol Actions: |
Protein disulfide isomerase (PDI) inhibitor; suppresses apoptosis induced by misfolded proteins |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
