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IMB-10

SIGMA/SML0022 - ≥98% (HPLC)

Synonym: 3-(2-methylphenyl)-5-(3-phenyl-2-propen-1-ylidene)-2-thioxo-4-thiazolidinone

CAS Number: 307525-40-2
Empirical Formula (Hill Notation): C19H15NOS2
Molecular Weight: 337.46
MDL Number: MFCD20134199
Linear Formula: C19H15NOS2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0022-5MG 5 mg
 $141.00
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assay ≥98% (HPLC)
color yellow
form powder
InChI 1S/C19H15NOS2/c1-14-8-5-6-12-16(14)20-18(21)17(23-19(20)22)13-7-11-15-9-3-2-4-10-15/h2-13H,1H3/b11-7+,17-13+
InChI key UYZLENPCNZVWQZ-QHMSGILQSA-N
Quality Level 100 
SMILES string Cc1ccccc1N2C(=S)SC(=CC=Cc3ccccc3)C2=O
solubility DMSO: ≥25 mg/mL
storage temp. 2-8°C
Application: IMB-10 may be used to study integrin-mediated signaling in tumor cells.
Biochem/physiol Actions: IMB-10 is a ligand for the αMβ2 integrin that stabilizes the binding of the integrin to endogenous ligands such as proMMP-9 and fibrinogen. IMB-10 blocks migration of lymphocyte cell lines and inhibits leukocyte infiltration in a murine thioglycolate-induced peritonitis.
Biochem/physiol Actions: IMB-10 is a thioxothiazolidine compound that inhibits the infiltration of leukocytes to the site of tumor and blocks the invasion of HSC-3 carcinoma. It modulates the host inflammatory responses and tumor progression.
Biochem/physiol Actions: Stabilizing Ligand of αMβ2 integrin
Packaging: 5, 25 mg in glass bottle
Safety Statements 61
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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