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Safinamide mesylate salt

SIGMA/SML0025 - ≥98% (HPLC)

Synonym: (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide; FCE-26743; PNU-151774E, NW-1015;

CAS Number: 202825-46-5
Empirical Formula (Hill Notation): C17H19FN2O2 · xCH4O3S
Molecular Weight: 302.34 (free base basis)
MDL Number: MFCD15145475
Linear Formula: C17H19FN2O2 · xCH4O3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0025-5MG 5 mg
 $146.00
1/EA		 Add To Favorites
45-SML0025-25MG 25 mg
 $568.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m0./s1
InChI key YKOCHIUQOBQIAC-YDALLXLXSA-N
optical activity [α]/D +9.5 to +14°, c = 1 (95% acetic acid)
Quality Level 100 
SMILES string CS(O)(=O)=O.C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O
solubility H2O: ≥15 mg/mL
storage temp. 2-8°C
Application: Safinamide mesylate salt has been used as a reference drug to study its inhibitory effect on human monoamine oxidases (hMAO-A and hMAO-B).
Application: Safinamide mesylate salt may be used in cell signaling studies.
Biochem/physiol Actions: Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.
Biochem/physiol Actions: Safinamide is a sodium and calcium channel blocker that is also a selective and reversible inhibitor of monoamine oxidase type B (MAO-B); anticonvulsant
Biochem/physiol Actions: Safinamide mesylate prevents dopamine reuptake and is effective in the treatment of epilepsy and Parkinson′s disease.
Features and Benefits: This compound is featured on the Calcium Channels  and Dopamine and Norepinephrine Metabolism  pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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