DBeQ

SIGMA/SML0031 - ≥98% (HPLC)

Synonym: JRF 12; N2,N4-dibenzylquinazoline-2,4-diamine

CAS Number: 177355-84-9
Empirical Formula (Hill Notation): C₂₂H₂₀N₄
Molecular Weight: 340.42
MDL Number: MFCD03691820
Linear Formula: C₂₂H₂₀N₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0031-5MG	5 mg	$122.00 1/EA		Add To Favorites
45-SML0031-25MG	25 mg	$497.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)
InChI key	QAIMUUJJAJBPCL-UHFFFAOYSA-N
Quality Level	100
SMILES string	C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4
solubility	DMSO: ≥20 mg/mL
storage temp.	room temp

Application:	HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.
Biochem/physiol Actions:	ATPase p97 inhibitor.
Biochem/physiol Actions:	DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.
Packaging:	5, 25 mg in glass bottle

Hazard Codes	Xn
Risk Statements	22-36
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	12352200

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