Tiagabine hydrochloride

SIGMA/SML0035 - ≥98% (HPLC)

Synonym: (-)-(R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid hydrochloride; (3R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-buten-1-yl]-3-piperidinecarboxylic acid hydrochloride

CAS Number: 145821-59-6
Empirical Formula (Hill Notation): C₂₀H₂₅NO₂S₂ · HCl
Molecular Weight: 412.01
MDL Number: MFCD07369025
Linear Formula: C₂₀H₂₅NO₂S₂ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0035-10MG	10 mg	$84.60 1/EA	Add To Favorites
45-SML0035-50MG	50 mg	$361.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1
InChI key	YUKARLAABCGMCN-PKLMIRHRSA-N
optical activity	[α]/D -9 to -12°, c = 1 in H₂O
originator	Cephalon
Quality Level	100
SMILES string	Cl.Cc1ccsc1C(=CCCN2CCC[C@H](C2)C(O)=O)c3sccc3C
solubility	H₂O: 10 mg/mL, clear
storage temp.	2-8°C

Application:	Tiagabine hydrochloride was used to study serotoninergic transmission in G1 cells. It has also been used to study its anti-aging effects on the sensory neurons of C. elegans.
Biochem/physiol Actions:	Selective inhibitor of the synaptic GABA transporter GAT1; Anticonvulsant
Biochem/physiol Actions:	Tiagabine hydrochloride is an anticonvulsant and selective GABA reuptake inhibitor through inhibition of the synaptic GABA transporter GAT1.
Biochem/physiol Actions:	Tiagabine increases the synaptic GABA and enhances the neuronal inhibition. It is effective as adjunctive treatment of epilepsy and anxiety disorders.
Features and Benefits:	This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the GABA Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Cephalon . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	10, 50 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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