Lazabemide hydrate
SIGMA/SML0042 - ≥97% (HPLC)
Synonym: N-
CAS Number: 103878-84-8 (anhydrous)
Empirical Formula (Hill Notation): C8H10ClN3O · xH2O
Molecular Weight: 199.64 (anhydrous basis)
MDL Number: MFCD20488051
Linear Formula: C8H10ClN3O · xH2O
Product Type: Chemical
| assay | ≥97% (HPLC) |
| color | white to tan |
| form | powder |
| InChI | 1S/C8H10ClN3O.H2O/c9-6-1- |
| InChI key | JYWYNPKXSLPWGV-UHFFFAOYSA |
| originator | Roche |
| Quality Level | 100  |
| SMILES string | O.NCCNC(=O)c1ccc(Cl)cn1 |
| solubility | DMSO: ≥22 mg/mL |
| storage condition | desiccated |
| storage temp. | room temp |
| Application: | Lazabemide hydrate may be used in cell signaling studies. |
| Biochem/physiol Actions: | Lazabemide is a selective and reversible monoamine oxidase B (MAO-B) inhibitor and Anti-Parkinson. Also it inhibits monoamine uptake at high concentrations (IC50 values are 86, 123 and > 500 μM for noradrenalin, serotonin and dopamine uptake respectively). |
| Biochem/physiol Actions: | Lazabemide is effective in treatment of Alzheimer′s disease and in combination with nicotine replacement therapy aids in smoking cessation. |
| Biochem/physiol Actions: | Selective MAO-B inhibitor; Antiparkinson |
| Features and Benefits: | This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by Roche . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H319 |
| Precautionary statements | P301 + P312 + P330 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |